| ncRNA name | BACE1 siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | immunohistochemistry, qPCR, immunoprecipitation, Western blot, siRNA transfection |
| Expression pattern | associated |
| Functional description | BACE1 plays a critical role in retinal homeostasis. Intravitreal administration of BACE1 inhibitor or BACE1 small interfering RNA (siRNA) increases choroidal neovascularization in mice. |
| PubMed ID | 22903875 |
| Year | 2012 |
| Title | β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. |
| Drug-related ncRNA | NO |
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